The European preexposure prophylaxis revolution
Identifieur interne : 000002 ( France/Analysis ); précédent : 000001; suivant : 000003The European preexposure prophylaxis revolution
Auteurs : Gus Cairns [Royaume-Uni, Belgique] ; Sheena Mccormack [Royaume-Uni] ; Jean-Michel Molina [France]Source :
- Current Opinion in HIV and AIDS [ 1746-630X ] ; 2016.
Abstract
The review describes the European epidemic and the challenges in moving from clinical trials of preexposure prophylaxis (PrEP) to routine practice.
Two European trials conducted in gay and other MSM and transgender women reported a high and consistent reduction in HIV incidence using oral PrEP with tenofovir/emtricitabine (TDF/FTC). The incidence of HIV infection in the control group was much higher than anticipated, based on routine surveillance data in MSM, in spite of the highest standard of HIV prevention available.
Recent results have highlighted the urgent need to make PrEP available to key populations in Europe as an additional prevention tool. Gilead has not yet submitted an application to use TDF/FTC as PrEP in Europe. Although regulatory approval would accelerate implementation, countries are already dispensing TDF/FTC as postexposure prophylaxis without this. Services for prevention are diverse across countries ranging from free, walk-in services for the diagnosis and treatment of HIV and other sexually transmitted infections, to insurance-dependent reimbursement of private clinical services. Momentum is gathering in Europe with PrEP demonstration projects in MSM and a growing demand from community organizations. Each Member State urgently needs to identify their key populations and determine the service best placed to provide this new prevention strategy within a comprehensive prevention package.
Url:
DOI: 10.1097/COH.0000000000000223
PubMed: 26599164
PubMed Central: 4888928
Affiliations:
- Belgique, France, Royaume-Uni
- Angleterre, Grand Londres, Région de Bruxelles-Capitale
- Bruxelles, Londres, Paris
- University College de Londres
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000089
- to stream Pmc, to step Curation: 000089
- to stream Pmc, to step Checkpoint: 000008
- to stream Ncbi, to step Merge: 000377
- to stream Ncbi, to step Curation: 000377
- to stream Ncbi, to step Checkpoint: 000377
- to stream Main, to step Merge: 000009
- to stream Main, to step Curation: 000009
- to stream Main, to step Exploration: 000009
- to stream France, to step Extraction: 000002
Links to Exploration step
PMC:4888928Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The European preexposure prophylaxis revolution</title><author><name sortKey="Cairns, Gus" sort="Cairns, Gus" uniqKey="Cairns G" first="Gus" last="Cairns">Gus Cairns</name><affiliation wicri:level="3"><nlm:aff id="aff1">NAM Publications/Aidsmap.com, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NAM Publications/Aidsmap.com, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">European AIDS Treatment Group, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>European AIDS Treatment Group, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Mccormack, Sheena" sort="Mccormack, Sheena" uniqKey="Mccormack S" first="Sheena" last="Mccormack">Sheena Mccormack</name><affiliation wicri:level="4"><nlm:aff id="aff3">Medical Research Council Clinical Trials Unit at UCL, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Clinical Trials Unit at UCL, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Molina, Jean Michel" sort="Molina, Jean Michel" uniqKey="Molina J" first="Jean-Michel" last="Molina">Jean-Michel Molina</name><affiliation><nlm:aff id="aff4">INSERM U941, University of Paris Diderot, Sorbonne Paris Cité</nlm:aff><wicri:noCountry code="subfield">Sorbonne Paris Cité</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Infectious Diseases, Hôpital Saint Louis, APHP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Infectious Diseases, Hôpital Saint Louis, APHP, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26599164</idno><idno type="pmc">4888928</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888928</idno><idno type="RBID">PMC:4888928</idno><idno type="doi">10.1097/COH.0000000000000223</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000089</idno><idno type="wicri:Area/Pmc/Curation">000089</idno><idno type="wicri:Area/Pmc/Checkpoint">000008</idno><idno type="wicri:Area/Ncbi/Merge">000377</idno><idno type="wicri:Area/Ncbi/Curation">000377</idno><idno type="wicri:Area/Ncbi/Checkpoint">000377</idno><idno type="wicri:doubleKey">1746-630X:2016:Cairns G:the:european:preexposure</idno><idno type="wicri:Area/Main/Merge">000009</idno><idno type="wicri:Area/Main/Curation">000009</idno><idno type="wicri:Area/Main/Exploration">000009</idno><idno type="wicri:Area/France/Extraction">000002</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The European preexposure prophylaxis revolution</title><author><name sortKey="Cairns, Gus" sort="Cairns, Gus" uniqKey="Cairns G" first="Gus" last="Cairns">Gus Cairns</name><affiliation wicri:level="3"><nlm:aff id="aff1">NAM Publications/Aidsmap.com, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NAM Publications/Aidsmap.com, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">European AIDS Treatment Group, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>European AIDS Treatment Group, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Mccormack, Sheena" sort="Mccormack, Sheena" uniqKey="Mccormack S" first="Sheena" last="Mccormack">Sheena Mccormack</name><affiliation wicri:level="4"><nlm:aff id="aff3">Medical Research Council Clinical Trials Unit at UCL, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Clinical Trials Unit at UCL, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Molina, Jean Michel" sort="Molina, Jean Michel" uniqKey="Molina J" first="Jean-Michel" last="Molina">Jean-Michel Molina</name><affiliation><nlm:aff id="aff4">INSERM U941, University of Paris Diderot, Sorbonne Paris Cité</nlm:aff><wicri:noCountry code="subfield">Sorbonne Paris Cité</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Infectious Diseases, Hôpital Saint Louis, APHP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Infectious Diseases, Hôpital Saint Louis, APHP, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Current Opinion in HIV and AIDS</title><idno type="ISSN">1746-630X</idno><idno type="eISSN">1746-6318</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose of review</title><p>The review describes the European epidemic and the challenges in moving from clinical trials of preexposure prophylaxis (PrEP) to routine practice.</p></sec><sec><title>Recent findings</title><p>Two European trials conducted in gay and other MSM and transgender women reported a high and consistent reduction in HIV incidence using oral PrEP with tenofovir/emtricitabine (TDF/FTC). The incidence of HIV infection in the control group was much higher than anticipated, based on routine surveillance data in MSM, in spite of the highest standard of HIV prevention available.</p></sec><sec sec-type="summary"><title>Summary</title><p>Recent results have highlighted the urgent need to make PrEP available to key populations in Europe as an additional prevention tool. Gilead has not yet submitted an application to use TDF/FTC as PrEP in Europe. Although regulatory approval would accelerate implementation, countries are already dispensing TDF/FTC as postexposure prophylaxis without this. Services for prevention are diverse across countries ranging from free, walk-in services for the diagnosis and treatment of HIV and other sexually transmitted infections, to insurance-dependent reimbursement of private clinical services. Momentum is gathering in Europe with PrEP demonstration projects in MSM and a growing demand from community organizations. Each Member State urgently needs to identify their key populations and determine the service best placed to provide this new prevention strategy within a comprehensive prevention package.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Baral, Sd" uniqKey="Baral S">SD Baral</name></author><author><name sortKey="Poteat, T" uniqKey="Poteat T">T Poteat</name></author><author><name sortKey="Stromdahl, S" uniqKey="Stromdahl S">S Stromdahl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pharris, A" uniqKey="Pharris A">A Pharris</name></author><author><name sortKey="Spiteri, G" uniqKey="Spiteri G">G Spiteri</name></author><author><name sortKey="Noori, T" uniqKey="Noori T">T Noori</name></author><author><name sortKey="Amato Gauci, Aj" uniqKey="Amato Gauci A">AJ Amato-Gauci</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Aghaizu, A" uniqKey="Aghaizu A">A Aghaizu</name></author><author><name sortKey="Nardone, A" uniqKey="Nardone A">A Nardone</name></author><author><name sortKey="Copas, A" uniqKey="Copas A">A Copas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grant, Rm" uniqKey="Grant R">RM Grant</name></author><author><name sortKey="Lama, Jr" uniqKey="Lama J">JR Lama</name></author><author><name sortKey="Anderson, Pl" uniqKey="Anderson P">PL Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baeten, Jm" uniqKey="Baeten J">JM Baeten</name></author><author><name sortKey="Donnell, D" uniqKey="Donnell D">D Donnell</name></author><author><name sortKey="Ndase, P" uniqKey="Ndase P">P Ndase</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thigpen, Mc" uniqKey="Thigpen M">MC Thigpen</name></author><author><name sortKey="Kebaabetswe, Pm" uniqKey="Kebaabetswe P">PM Kebaabetswe</name></author><author><name sortKey="Paxton, La" uniqKey="Paxton L">LA Paxton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choopanya, K" uniqKey="Choopanya K">K Choopanya</name></author><author><name sortKey="Martin, M" uniqKey="Martin M">M Martin</name></author><author><name sortKey="Suntharasamai, P" uniqKey="Suntharasamai P">P Suntharasamai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Damme, L" uniqKey="Van Damme L">L Van Damme</name></author><author><name sortKey="Corneli, A" uniqKey="Corneli A">A Corneli</name></author><author><name sortKey="Ahmed, K" uniqKey="Ahmed K">K Ahmed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marrazzo, Jm" uniqKey="Marrazzo J">JM Marrazzo</name></author><author><name sortKey="Ramjee, G" uniqKey="Ramjee G">G Ramjee</name></author><author><name sortKey="Richardson, Ba" uniqKey="Richardson B">BA Richardson</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mccormack, S" uniqKey="Mccormack S">S McCormack</name></author><author><name sortKey="Fidler, S" uniqKey="Fidler S">S Fidler</name></author><author><name sortKey="Fisher, M" uniqKey="Fisher M">M Fisher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Molina, Jm" uniqKey="Molina J">JM Molina</name></author><author><name sortKey="Pintado, C" uniqKey="Pintado C">C Pintado</name></author><author><name sortKey="Gatey, C" uniqKey="Gatey C">C Gatey</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Gomez, Gb" uniqKey="Gomez G">GB Gomez</name></author><author><name sortKey="Borquez, A" uniqKey="Borquez A">A Borquez</name></author><author><name sortKey="Case, Kk" uniqKey="Case K">KK Case</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lorente, N" uniqKey="Lorente N">N Lorente</name></author><author><name sortKey="Fugon, L" uniqKey="Fugon L">L Fugon</name></author><author><name sortKey="Carrieri, Mp" uniqKey="Carrieri M">MP Carrieri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccormack, S" uniqKey="Mccormack S">S McCormack</name></author><author><name sortKey="Dunn, D" uniqKey="Dunn D">D Dunn</name></author><author><name sortKey="Desai, M" uniqKey="Desai M">M Desai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Molina, J M" uniqKey="Molina J">J-M Molina</name></author><author><name sortKey="Capitant, C" uniqKey="Capitant C">C Capitant</name></author><author><name sortKey="Charreau, I" uniqKey="Charreau I">I Charreau</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Aghaizu, A" uniqKey="Aghaizu A">A Aghaizu</name></author><author><name sortKey="Murphy, G" uniqKey="Murphy G">G Murphy</name></author><author><name sortKey="Tosswill, J" uniqKey="Tosswill J">J Tosswill</name></author><author><name sortKey="Deangelis, D" uniqKey="Deangelis D">D DeAngelis</name></author><author><name sortKey="Charlett, A" uniqKey="Charlett A">A Charlett</name></author><author><name sortKey="Gill, N" uniqKey="Gill N">N Gill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="J, F" uniqKey="J F">F J</name></author><author><name sortKey="Capitant, C" uniqKey="Capitant C">C Capitant</name></author><author><name sortKey="Spire, B" uniqKey="Spire B">B Spire</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Puro, V" uniqKey="Puro V">V Puro</name></author><author><name sortKey="Palummieri, A" uniqKey="Palummieri A">A Palummieri</name></author><author><name sortKey="De Carli, G" uniqKey="De Carli G">G De Carli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Desai, M" uniqKey="Desai M">M Desai</name></author><author><name sortKey="Gafos, M" uniqKey="Gafos M">M Gafos</name></author><author><name sortKey="Dolling, D" uniqKey="Dolling D">D Dolling</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Boseley, S" uniqKey="Boseley S">S Boseley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Platell, A" uniqKey="Platell A">A Platell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ouellet, E" uniqKey="Ouellet E">E Ouellet</name></author><author><name sortKey="Durand, M" uniqKey="Durand M">M Durand</name></author><author><name sortKey="Guertin, Jr" uniqKey="Guertin J">JR Guertin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cambiano, V" uniqKey="Cambiano V">V Cambiano</name></author><author><name sortKey="Miners, A" uniqKey="Miners A">A Miners</name></author><author><name sortKey="Dunn, D" uniqKey="Dunn D">D Dunn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ong, K J" uniqKey="Ong K">K-J Ong</name></author><author><name sortKey="Desai, S" uniqKey="Desai S">S Desai</name></author><author><name sortKey="Desai, M" uniqKey="Desai M">M Desai</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Belgique</li><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bruxelles</li><li>Londres</li><li>Paris</li></settlement><orgName><li>University College de Londres</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Cairns, Gus" sort="Cairns, Gus" uniqKey="Cairns G" first="Gus" last="Cairns">Gus Cairns</name></region><name sortKey="Mccormack, Sheena" sort="Mccormack, Sheena" uniqKey="Mccormack S" first="Sheena" last="Mccormack">Sheena Mccormack</name></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Cairns, Gus" sort="Cairns, Gus" uniqKey="Cairns G" first="Gus" last="Cairns">Gus Cairns</name></region></country><country name="France"><noRegion><name sortKey="Molina, Jean Michel" sort="Molina, Jean Michel" uniqKey="Molina J" first="Jean-Michel" last="Molina">Jean-Michel Molina</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Belgique/explor/OpenAccessBelV2/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000002 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000002 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Belgique
|area= OpenAccessBelV2
|flux= France
|étape= Analysis
|type= RBID
|clé= PMC:4888928
|texte= The European preexposure prophylaxis revolution
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i -Sk "pubmed:26599164" \
| HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a OpenAccessBelV2
| This area was generated with Dilib version V0.6.25. |  |